Journal of Medicinal Chemistry
Volume 39, Issue 18 (August 30, 1996)
Copyright © 1996 American Chemical Society

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3431-3434

New Series of Potent, Orally Bioavailable, Non-Peptidic Cyclic Sulfones as HIV-1 Protease Inhibitors Choung U. Kim, Lawrence R. McGee, Steven H. Krawczyk, Erik Harwood, Yoko Harada, S. Swaminathan, Norbert Bischofberger, Ming S. Chen, Julie M. Cherrington, Shelly F. Xiong, Linda Griffin, Kenneth C. Cundy, Angela Lee, Betty Yu, Sergli Gulnik, and John W. Erickson [Full Article - PDF]

3435-3450

Synthesis, Biological Activity, and SARs of Pyrrolobenzoxazepine Derivatives, a New Class of Specific "Peripheral-Type" Benzodiazepine Receptor Ligands Giuseppe Campiani, Vito Nacci, Isabella Fiorini, Maria P. De Filippis, Antonio Garofalo, Silvia M. Ciani, Giovanni Greco, Ettore Novellino, D. Clive Williams, Daniela M. Zisterer, Margaret J. Woods, Camelia Mihai, Cristina Manzoni, and Tiziana Mennini [Full Article - PDF]

3451-3460

Reassessment of Diethylenetriaminepentaacetic Acid (DTPA) as a Chelating Agent for Indium-111 Labeling of Polypeptides Using a Newly Synthesized Monoreactive DTPA Derivative Yasushi Arano, Takashi Uezono, Hiromichi Akizawa, Masahiro Ono, Kouji Wakisaka, Morio Nakayama, Harumi Sakahara, Junji Konishi, and Akira Yokoyama [Full Article - PDF]

3461-3469

Novel 5-Aminoflavone Derivatives as Specific Antitumor Agents in Breast Cancer Tsutomu Akama, Yasushi Shida, Toru Sugaya, Hiroyuki Ishida, Katsushige Gomi, and Masaji Kasai [Full Article - PDF]

3470-3476

Synthesis of Non-nucleoside Analogs of Toyocamycin, Sangivamycin, and Thiosangivamycin: The Effect of Certain 4- and 4,6-Substituents on the Antiviral Activity of Pyrrolo[2,3-d]pyrimidines Thomas E. Renau, Christopher Kennedy, Roger G. Ptak, Julie M. Breitenbach, John C. Drach, and Leroy B. Townsend [Full Article - PDF]

3477-3482

Synthesis and Antiviral Evaluation of Certain Disubstituted Benzimidazole Ribonucleosides Ruiming Zou, Kevin R. Ayres, John C. Drach, and Leroy B. Townsend [Full Article - PDF]

3483-3490

Effects of Multidrug Resistance (MDR1) P-Glycoprotein Expression Levels and Coordination Metal on the Cytotoxic Potency of Multidentate (N4O2) (Ethylenediamine)bis[propyl(R-benzylimino)]metal(III) Cations Vijay Sharma, Carolyn L. Crankshaw, and David Piwnica-Worms [Full Article - PDF]

3491-3502

10-Substituted 11-Oxygenated (R)-Aporphines: Synthesis, Pharmacology, and Modeling of 5-HT1A Receptor Interactions Martin H. Hedberg, Johanna M. Jansen, Gunnar Nordvall, Stephan Hjorth, Lena Unelius, and Anette M. Johansson [Full Article - PDF]

3503-3513

11-Substituted (R)-Aporphines: Synthesis, Pharmacology, and Modeling of D2A and 5-HT1A Receptor Interactions Martin H. Hedberg, Tero Linnanen, Johanna M. Jansen, Gunnar Nordvall, Stephan Hjorth, Lena Unelius, and Anette M. Johansson [Full Article - PDF]

3514-3525

Cyclic HIV Protease Inhibitors: Synthesis, Conformational Analysis, P2/P2' Structure-Activity Relationship, and Molecular Recognition of Cyclic Ureas Patrick Y. S. Lam, Yu Ru, Prabhakar K. Jadhav, Paul E. Aldrich, George V. DeLucca, Charles J. Eyermann, Chong-Hwan Chang, George Emmett, Edward R. Holler, Wayne F. Daneker, Liangzhu Li, Pat N. Confalone, Robert J. McHugh, Qi Han, Renhua Li, Jay A. Markwalder, Steven P. Seitz, Thomas R. Sharpe, Lee T. Bacheler, Marlene M. Rayner, Ronald M. Klabe, Linyee Shum, Dean L. Winslow, David M. Kornhauser, David A. Jackson, Susan Erickson-Viitanen, and C. Nicholas Hodge [Full Article - PDF]

3526-3532

Nonlinear Quantitative Structure-Activity Relationship for the Inhibition of Dihydrofolate Reductase by Pyrimidines Jonathan D. Hirst [Full Article - PDF]

3533-3538

Synthesis and Evaluation of 2-[(5-Methylbenz-1-ox-4-azin-6-yl)imino]imidazoline, a Potent, Peripherally Acting 2 Adrenoceptor Agonist Stephen A. Munk, Dale Harcourt, György Ambrus, Lydia Denys, Charles Gluchowski, James A. Burke, Alexander B. Kharlamb, Cynthia A. Manlapaz, Edwin U. Padillo, Eileen Runde, Linda Williams, Larry A. Wheeler, and Michael E. Garst [Full Article - PDF]

3539-3546

Effect of Ring Size or an Additional Heteroatom on the Potency and Selectivity of Bicyclic Benzylamine-Type Inhibitors of Phenylethanolamine N-Methyltransferase1a Gary L. Grunewald, Vilas H. Dahanukar, Piao Ching,1b and Kevin R. Criscione [Full Article - PDF]

3547-3555

Orally Active, Nonpeptide Vasopressin V2 Receptor Antagonists: A Novel Series of 1-[4-(Benzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-benzazepines and Related Compounds Hidenori Ogawa, Hiroshi Yamashita, Kazumi Kondo, Yoshitaka Yamamura, Hisashi Miyamoto, Keizo Kan, Kazuyoshi Kitano, Michinori Tanaka, Kenji Nakaya, Shigeki Nakamura, Toyoki Mori, Michiaki Tominaga, and Youichi Yabuuchi [Full Article - PDF]

3556-3563

Synthesis and Structure-Activity Relationships of Retinoid X Receptor Selective Diaryl Sulfide Analogs of Retinoic Acid Richard L. Beard, Diana F. Colon, Tae K. Song, Peter J. A. Davies, Devendra M. Kochhar, and Roshantha A. S. Chandraratna [Full Article - PDF]

3564-3568

Synthesis and Evaluation of Aryl-Substituted N-(Arylethyl)-N-methyl-2-(1-pyrrolidinyl)ethylamines and Corresponding Arylacetamides for Sigma Receptor Affinity Ying Zhang, Wanda Williams, Wayne D. Bowen, and Kenner C. Rice [Full Article - PDF]

3569-3584

ATP-Citrate Lyase as a Target for Hypolipidemic Intervention. Design and Synthesis of 2-Substituted Butanedioic Acids as Novel, Potent Inhibitors of the Enzyme Andrew D. Gribble, Roland E. Dolle, Antony Shaw, David McNair, Riccardo Novelli, Christine E. Novelli, Brian P. Slingsby, Virendra P. Shah, David Tew, Barbara A. Saxty, Mark Allen, Pieter H. Groot, Nigel Pearce, and John Yates [Full Article - PDF]

3585-3591

Synthesis and Contractile Activities of Cyclic Thrombin Receptor-Derived Peptide Analogues with a Phe-Leu-Leu-Arg Motif: Importance of the Phe/Arg Relative Conformation and the Primary Amino Group for Activity John M. Matsoukas, Dimitris Panagiotopoulos, Maria Keramida, Thomas Mavromoustakos, Raghav Yamdagni, Qiao Wu, Graham J. Moore, Mahmoud Saifeddine, and Morley D. Hollenberg [Full Article - PDF]

3592-3595

Synthesis and Pharmacological Testing of Dequalinium Analogues as Blockers of the Apamin-Sensitive Ca2+-Activated K+ Channel: Variation of the Length of the Alkylene Chain Dimitrios Galanakis, C. Robin Ganellin, Sajeed Malik, and Philip M. Dunn [Full Article - PDF]

3596-3600

The Chemistry of Pseudomonic Acid. 17. Dual-Action C-1 Oxazole Derivatives of Pseudomonic Acid Having an Extended Spectrum of Antibacterial Activity Nigel J. P. Broom, Robert Cassels, Hung-Yuan Cheng, John S. Elder, Peter C. T. Hannan, Nicki Masson, Peter J. O'Hanlon, Andrew Pope, and Jennifer M. Wilson [Full Article - PDF]

3601-3601

Free Radicals and Oxidative Stress: Environment, Drugs and Food Additives. Biochemical Society Symposium No. 61 Organized and edited by C. Rice-Evans, B. Halliwell, and G. G. Lunt. Portland Press Ltd., London, on behalf of the Biochemical Society. 1995. x + 276 pp. 16 × 25.5 cm. ISBN 1-85578-069-0. $96.00. Staff [Full Article - PDF]

3601-3601

Chemistry of Organic Fluorine Compounds II: A Critical Review Edited by M. Hudlicky and A. E. Pavlath. American Chemical Society Monograph 187. American Chemical Society, Washington, D.C. 1995. xxi + 1296 pp. 16.0 × 23.5 cm. ISBN 0-8412-2515-X. $169.95. Adeboye Adejare [Full Article - PDF]

3601-3602

Enantioselective Reactions in Organic Chem-istry By Otakar Cervinka. Ellis Horwood, New York. 1995. xii + 194 pp. 17 × 24 cm. ISBN 0-13-276239-0. $119.95. Ciro J. Spagnuolo [Full Article - PDF]

3602-3602

Organic Chemistry. Sixth Edition By T. W. Graham Solomons. John Wiley & Sons, New York. 1995. xxvii + 1290 pp. 18.5 × 26 cm. ISBN 0-471-01342-0. $90.95. John R. Williams [Full Article - PDF]